Tango
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Tango
Disruptions in iron homeostasis from both iron deficiency and overload account for some of the most common human diseases. Iron metabolism is balanced by two regulatory systems, one that functions systemically and relies on the hormone hepcidin and the iron exporter ferroportin, and another that predominantly controls cellular iron metabolism through iron-regulatory proteins that bind iron-responsive elements in regulated messenger RNAs. We describe how the two distinct systems function and how they "tango" together in a coordinated manner. We also highlight some of the current questions in mammalian iron metabolism and discuss therapeutic opportunities arising from a better understanding of the underlying biological principles.
syncopated ballroom dance, 1913 (the year it became a rage in Britain and America), from Argentine Spanish tango, originally the name of an African-South American drum dance, probably from a Niger-Congo language (compare Ibibio tamgu "to dance"). Phrase it takes two to tango was a song title from 1952. As a verb from 1913. Related: Tangoed. 041b061a72